Nursing
Thank you for receiving my order, this assignment is going to be a concept map of a hematologic disorder, in the ”order instructions” you will find questions as well as which information is needed, and you will find the concept map in the ”guidelines for writing” tab.
ANSWER
Module 09 Written Assignment – Hematologic Disorder
Your Name
Rasmussen University
NUR2063 Essentials of Pathophysiology
Professor Carla Points
Assignment Due Date
Hematology Concept Map Template
Student Name:
Disorder/Disease process: Sickle Cell Anemia Disease
| PATHOPHYSIOLOGY OF THE DISORDER:
· Sickle cell is an inherited generic condition that include defects in the function and shape of the hemoglobin in the blood. · Sickle Cell anemia results from alteration in the beta-globin sequence of the hemoglobin molecule (Steinberg, 2016). This increase the possibility of disrupted blood flow and blockages in the blood vessels which can lead to serious complications. · The initial signs and symptoms of sickle cell disease tend to develop in young children between the ages of six months and one year old with a high concentration of fetal hemoglobin playing a protective role during this time.
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| ETIOLOGY:
· Sickle cell disease results from abnormal hemoglobin in the hemoglobin beta gene in chromosome 11 (Costa and Conran, 2016). · The change in gene tells the body to produce iron-rich compound in the red blood cells. · The hemoglobin with sickle cell disease causes red blood cells to be sticky, misshapen and rigid.
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| CLINICAL MANIFESTATIONS:
· Vaso-occlusive crisis is a common clinical manifestation which occurs after microcirculation is obstructed by Sickled RBCs leading to ischemic injury to the supplied organ. · The major features of Sickle cell disease are linked to vaso-occlusion, anemia and pain crises, swelling feet and hand, delayed puberty and growth.
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| TREATMENTS:
Treatment and management of Sickle cell anemia is usually focused on relieving symptoms, avoiding pain episodes and eliminating complications. Antibiotics, blood transfusions and medications are used to treat infections and lower the symptoms and complications of sickle cell anemia (Tisdale, Thein and Eaton, 2020). Bone marrow or stem cell transplants are the most effective in curing sickle cell disease. Medications such as Hydroxyurea, Endari and Crizanlizumab are effective in the management of sickle cell anemia. For instance, Hydroxyurea lowers the frequency of painful crisis and reduces hospitalization and blood transfusions (McGann and Ware, 2015). |
References
Costa, F. F., & Conran, N. (Eds.). (2016). Sickle cell anemia: From basic science to clinical practice. Springer.
McGann, P. T., & Ware, R. E. (2015). Hydroxyurea therapy for sickle cell anemia. Expert opinion on drug safety, 14(11), 1749-1758.
Steinberg, M. H. (2016). Overview of sickle cell anemia pathophysiology. In Sickle cell anemia (pp. 49-73). Springer, Cham.
Tisdale, J. F., Thein, S. L., & Eaton, W. A. (2020). Treating sickle cell anemia. Science, 367(6483), 1198-1199.
